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. 2020 Jul 29;10:384. doi: 10.3389/fcimb.2020.00384

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Copyright © 2020 Dunn and Munger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calcium and AMPK signaling during HCMV infection. Calcium signaling contributes to increased intracellular calcium release through HCMV encoded genes, UL146, US28, UL37, and US21, and through viral entry via epidermal growth factor receptor (EGFR). HCMV infection also induces the expression of CaMKK and AMPK, both of which are crucial for viral replication through multiple cellular signals. HCMV infection also impacts neural cell development which is associated with loss of proper calcium response. Inhibition of CaMKK by STO-609 inhibits HMCV viral replication. AMPK inhibition by Compound C, or activation by metformin or AICAR, also results in a decrease in HCMV viral replication.