FIGURE 4.

Proteomic prediction of ZIKV-induced changes in the neurosensory system. (A) Heatmaps of significantly dysregulated proteins involved in the development of neurosensory system. Most significant changes belonged to the 48 hpi dataset. Specific heatmaps that cover different subsets of neurosensory system are shown in upper panels. Lower panel represents the global overview heatmap for all proteins regulating the development of neurosensory system across three time-points from ZIKV-infected Vero cells. (B) Graphical representation of predicted ZIKV-triggered dysregulations in different parts of the neurosensory system by 2 dpi. Lower bordered panel indicates that a few proteins (ones with red margins) with influences on sensory nervous system together with some other differentially expressed proteins at 48 hpi could influence cognitive and learning functions based on IPA predictions. (C) Protein-protein interaction assessment of significantly regulated proteins causing neurosensory impairments based on their levels at 48 hpi. (D) Gene ontology analysis within the single class of biological process showing top affected pathways based on significantly dysregulated proteins with functions in neurosensory system at 48 hpi.