Table 5.

The most significant enriched GO terms for the DEGs of DSS and MPTP vs control and MPTP + DSS vs MPTP.

GO term	Description	Corrected p-value	DEGs count
DSS vs controla
GO:0031720	Haptoglobin binding	9.59E−06	4
GO:0005344	Oxygen carrier activity	3.37E−06	4
GO:0019825	Oxygen binding	2.73E−05	4
GO:0016209	Antioxidant activity	9.96E−05	5
GO:0140104	Molecular carrier activity	1.63E−04	4
GO:0004601	Peroxidase activity	2.19E−04	4
GO:0031722	Hemoglobin beta binding	2.19E−04	2
GO:0016684	Oxidoreductase activity, acting on peroxide as acceptor	2.52E−04	4
GO:0031721	Hemoglobin alpha binding	1.02E−03	2
GO:0030492	Hemoglobin binding	2.78E−03	2
GO:0015106	Bicarbonate transmembrane transporter activity	2.78E−03	2
GO:0005515	Protein binding	2.78E−03	35
GO:0005452	Inorganic anion exchanger activity	7.66E−03	2
MPTP + DSS vs controla
GO:0042802	Identical protein binding	7.99E−07	97
GO:0016209	Antioxidant activity	8.02E−07	16
GO:0005515	Protein binding	2.33E−06	348
GO:0030414	Peptidase inhibitor activity	1.78E−05	22
GO:0004857	Enzyme inhibitor activity	1.93E−05	31
GO:0061134	Peptidase regulator activity	4.69E−05	23
GO:0004866	Endopeptidase inhibitor activity	6.02E−05	20
GO:0061135	Endopeptidase regulator activity	1.28E−04	20
GO:0048037	Cofactor binding	3.16E−04	37
GO:0005488	Binding	4.53E−04	460
GO:0016491	Oxidoreductase activity	5.62E−04	46
GO:0003824	Catalytic activity	1.12E−03	209
GO:0030234	Enzyme regulator activity	1.12E−03	50
GO:0042803	Protein homodimerization activity	1.22E−03	48
GO:0004869	Cysteine-type endopeptidase inhibitor activity	1.35e−03	10
GO:0016722	Oxidoreductase activity, oxidizing metal ions	1.50E−03	6
GO:0016684	Oxidoreductase activity, acting on peroxide as acceptor	1.75E−03	9
GO:0005506	Iron ion binding	1.75E−03	18
GO:0004322	Ferroxidase activity	2.04E−03	5
GO:0016724	Oxidoreductase activity, oxidizing metal ions, oxygen as acceptor	2.04E−03	5
GO:1901567	Fatty acid derivative binding	2.53E−03	7
GO:0031720	Haptoglobin binding	3.21E−03	4
GO:0046906	Tetrapyrrole binding	3.49E−03	16
GO:0004165	Dodecenoyl-coa delta-isomerase activity	3.73E−03	3
GO:0004601	Peroxidase activity	4.13E−03	8
GO:0020037	Heme binding	6.13E−03	15
GO:0043177	Organic acid binding	6.15E−03	17
GO:0046914	Transition metal ion binding	6.71E−03	50
MPTP + DSS vs MPTPa
GO:0031720	Haptoglobin binding	4.89E−04	3

^aResults shown with corrected p-value ≤ 1E−03.