Table 6.
Functional enriched Reactome annotations for all the comparisons.
| Reactome code | Description | Corrected p-value | DEGs count |
|---|---|---|---|
| DSS vs control | |||
| 1247673 | Erythrocytes take up oxygen and release carbon dioxide | 7.33E−08 | 5 |
| 1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.92E−07 | 5 |
| 1480926 | O2/CO2 exchange in erythrocytes | 1.92E−07 | 5 |
| 2168880 | Scavenging of heme from plasma | 8.25E−05 | 5 |
| 2173782 | Binding and uptake of ligands by scavenger receptors | 1.52E−04 | 5 |
| 189451 | Heme biosynthesis | 1.08E−02 | 2 |
| 189445 | Metabolism of porphyrins | 2.54E−02 | 2 |
| 216083 | Integrin cell surface interactions | 3.02E−02 | 3 |
| 168256 | Immune system | 3.02E−02 | 13 |
| MPTP vs control | |||
| 140342 | Apoptosis induced DNA fragmentation | 1.45E−05 | 5 |
| 2559584 | Formation of senescence-associated heterochromatin foci (SAHF) | 4.68E−05 | 5 |
| 2559586 | DNA damage/telomere stress induced senescence | 4.58E−03 | 6 |
| 75153 | Apoptotic execution phase | 5.18E−03 | 5 |
| MPTP + DSS vs control | |||
| 168256 | Immune system | 1.48E−07 | 111 |
| 168249 | Innate immune system | 1.14E−06 | 73 |
| 6798695 | Neutrophil degranulation | 2.75E−06 | 47 |
| 1247673 | Erythrocytes take up oxygen and release carbon dioxide | 2.91E−04 | 4 |
| 198933 | Immunoregulatory interactions between a lymphoid and a Non-lymphoid cell | 2.12E−03 | 19 |
| 5686938 | Regulation of TLR by endogenous ligand | 2.12E−03 | 6 |
| 804914 | Transport of fatty acids | 5.34E−03 | 4 |
| 425397 | Transport of vitamins, nucleosides, and related molecules | 8.93E−03 | 8 |
| 8978868 | Fatty acid metabolism | 1.33E−02 | 19 |
| 109582 | Hemostasis | 3.06E−02 | 39 |
| 216083 | Integrin cell surface interactions | 4.19E−02 | 10 |
| 1236975 | Antigen processing-cross presentation | 4.45E−02 | 7 |
| 2142688 | Synthesis of 5-eicosatetraenoic acids | 4.68E−02 | 3 |
| MPTP + DSS vs MPTP | |||
| 174577 | Activation of C3 and C5 | 7.20E−03 | 3 |
| 1247673 | Erythrocytes take up oxygen and release carbon dioxide | 1.21E−02 | 3 |
| 1480926 | O2/CO2 exchange in erythrocytes | 1.79E−02 | 3 |
| 1237044 | Erythrocytes take up carbon dioxide and release oxygen | 1.79E−02 | 3 |