Table 2.
Results of univariate analysis of PD-L1, PD-1, CD8, CD4 and CD3 in relation to durable clinical benefit are shown for the derivation cohort.
| Variables | Derivation cohort | ||||
|---|---|---|---|---|---|
| DCB rates (%) | Univariate OR (95% CI) | p value | Multivariate OR (95% CI) | p value | |
| Tumour PD-L1 expression | 0.014 | 0.041 | |||
| <1% (n = 50) | 18 | 1.0 | 1.00 | ||
| 1–49% (n = 8) | 0 | 0 | 0.00 | ||
| ≥50% (n = 8) | 75 | 13.6 (2.3–79.0) | 11.8 (1.7–79.7) | ||
| Stromal infiltration of PD-L1+ IC | 0.36 | ||||
| Low infiltration (n = 40) | 18 | 1.0 | |||
| Intermediate infiltration (n = 15) | 33 | 2.4 (0.61–9.1) | |||
| High infiltration (n = 9) | 33 | 2.4 (0.47–11.8) | |||
| Stromal infiltration of PD-1+ IC | 0.047 | ||||
| Low infiltration (n = 38) | 13 | 1.0 | |||
| Intermediate infiltration (n = 21) | 29 | 2.6 (0.70–10.0) | |||
| High infiltration (n = 7) | 57 | 8.8 (1.5–51.6) | |||
| Tumour infiltration of CD8+ IC | 0.11 | ||||
| Low infiltration (n = 35) | 14 | 1.0 | |||
| Intermediate infiltration (n = 18) | 22 | 1.7 (0.40–7.4) | |||
| High infiltration (n = 14) | 43 | 4.5 (1.1–18.6) | |||
| Stromal infiltration of CD8+ IC | 0.063 | ||||
| Low infiltration (n = 15) | 7 | 1.0 | |||
| Intermediate infiltration (n = 21) | 14 | 2.3 (0.22–24.9) | |||
| High infiltration (n = 30) | 37 | 8.1 (0.93–70.3) | |||
| Stromal infiltration of CD3+ IC | 0.046 | ||||
| Low infiltration (n = 22) | 5 | 1.0 | |||
| Intermediate infiltration (n = 21) | 24 | 6.6 (0.7–61.9) | |||
| High infiltration (n = 22) | 41 | 14.5 (1.7–128.4) | |||
| Stromal infiltration of CD4+ IC | 0.044 | ||||
| Low infiltration (n = 16) | 6 | 1.0 | |||
| Intermediate infiltration (n = 13) | 8 | 1.3 (0.071–22.1) | |||
| High infiltration (n = 36) | 36 | 8.5 (1.0–71.7) | |||
| Combined tumour and stromal infiltration of CD8+ IC | 0.030 | 0.073 | |||
| Low infiltration of tumour and stromal CD8+ IC (n = 28) | 14 | 1.0 | 1.0 | ||
| High infiltration of tumour or stromal CD8+ IC (n = 14) | 7 | 0.46 (0.047–4.6) | 0.32 (0.028–3.8) | ||
| High infiltration of tumour and stromal CD8+ IC (n = 24) | 42 | 4.3 (1.1–16.3) | 3.5 (0.78–15.9) | ||
| Combined stromal infiltration of PD-1+ and CD8+ IC | 0.027 | ||||
| Low infiltration of stromal PD-1+ and CD8+ IC (n = 28) | 11 | 1.0 | |||
| High infiltration of stromal PD-1+ or CD8+ IC (n = 17) | 18 | 1.8 (0.32–10.1) | |||
| High infiltration of stromal PD-1+ and CD8+ IC (n = 20) | 45 | 6.8 (1.5–30.2) | |||
| Combined stromal infiltration of PD-L1+ and CD8+ IC | 0.024 | ||||
| Low infiltration of stromal PD-L1+ and CD8+ IC (n = 30) | 7 | 1.0 | |||
| High infiltration of stromal PD-L1+ or CD8+ IC (n = 16) | 44 | 10.9 (1.9–62.1) | |||
| High infiltration of PD-L1+ and CD8+ IC (n = 18) | 33 | 7.0 (1.2–39.8) | |||
Statistically significant p < 0.05 values are in bold