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. 2020 Aug 4;10:13146. doi: 10.1038/s41598-020-69905-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Top 5 lncRNAs expressed in 17q12-21.3 vs copy number changes. (B) Expression of AC009283.1 in BRCA subtypes including hormone receptor and HER2 receptor status. (C) Bubble plot representing GSEA analysis in AC009283.1 high expression breast cancer samples versus AC009283.1 medium and low expression samples. Pink arrows depict biological processes previously shown in in vitro shRNA-mediated knockdown assays. (D) ssGSEA analysis for AC009283.1 high, medium and low expression levels, depicting enrichment for cellular proliferation, cell cycle and apoptosis processes in an independent HER2-enriched breast cancer cohort.