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. 2020 Aug 4;10:13143. doi: 10.1038/s41598-020-69735-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FOSL1 overexpression results. Overexpression of FOSL1 in HPMEC-im experiments, including (A) effect of LPS treatment, FOSL1 overexpression, and combined LPS treatment plus FOSL1 overexpression on angiogenesis or vasculogenesis gene expression (n = 5 per condition) (*p < 0.05 between LPS-treated and saline control; ^§p < 0.05, ^§§p < 0.01 between vector:LPS and FOSL1:LPS; by one-way ANOVA and post-hoc Tukey tests [HPX, RNF213, IL-1α] or Krukal-Wallis and post-hoc Mann–Whitney tests [ADAM8, CXCR2, LRG1, PROK2]); (B) ChIP experiments demonstrating pull-down of downstream target genes by FOSL1 (n = 5 per condition, presented as mean ± standard deviation with *p < 0.05, **p < 0.01, ***p < 0.001 by one-sample, two-tailed Student’s t test [LRG1, PROK2, RNF213] or one-sample Wilcoxon signed rank test [ADAM8]; and (C) ChIP experiments demonstrating increased binding of FOSL1 to target gene promoters after LPS stimulation (n = 5 per condition, presented as mean ± standard deviation with *p < 0.05, **p < 0.01, ***p < 0.001 by one-sample Wilcoxon signed rank test). Graphs created in SPSS 26 for Mac (https://www.ibm.com/analytics/spss-statistics-software) and image assembled in Adobe Illustrator 24.1.0 for Mac (https://www.adobe.com/products/illustrator.html).