Table 2.
Antiviral activity of selected hit compounds and control compounds.
| µM | EC50 | EC90 | CC50 | SI |
|---|---|---|---|---|
| Azithromycine | 2.12 | 8.65 | > 40 | > 19 |
| Spiramycin | 7.95 | 10.45 | > 40 | > 5 |
| Omeprazole | 17.06 | 38.01 | > 40 | > 2.35 |
| Oxprenolol hydrochloride | 20.22 | > 40 | > 40 | > 2 |
| Hydroxy-chloroquine | 4.17 | 25.49 | > 40 | > 10 |
| Clemizole hydrochloride | 23.94 | 38.23 | > 40 | > 1.7 |
| Alprostadil | 5.39 | 62.40 | > 40 | > 7.4 |
| Dolutegravir | 22.04 | 42.81 | > 40 | > 1.8 |
| Sulfadoxine | 35.37 | 45.11 | > 40 | > 1.13 |
| Opipramol dihydrochloride | 5.05 | 5.97 | > 40 | > 7.9 |
| Quinidine hydrochloride | 5.11 | > 40 | > 40 | > 7.8 |
| Vonoprazan | 38.58 | 41.01 | > 40 | > 1 |
| Exemestane | 7.51 | 9.86 | > 40 | 5.3 |
| Dyclonine hydrochloride | 10.00 | > 40 | > 40 | > 4 |
| Spiperone | 2.49 | 13.10 | > 40 | > 16 |
| Arbidol | 10.7 | 15.2 | > 40a | > 3.7 |
| Remdesivir 7 exp | 1.67 ± 0.59 | 2.53 ± 0.67 | nd | nd |
All value are in µM.
EC50 50% inhibition, EC90 90% inhibition, CC50 50% cytotoxicity, SI selectivity index, nd not determined.
aFrom Ref.33.