Table 2.

Univariable and multivariable analyses of clinicopathologic variables in relation to OS in patients with GC undergoing curative resection.

Clinicopathologic characteristics	Univariable analysis		Multivariable analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.02 (1.01–1.04)	0.003	1.02 (1.01–1.00)	0.003
Sex
Male	Reference
Female	0.90 (0.65–1.23)	0.51
BMI	0.93 (0.89–0.97)	0.002	0.96 (0.93–0.99)	0.01
ASA score
1	Reference
2	1.13 (0.86–1.47)	0.39
3	1.29 (0.66–2.53)	0.46
Tumour location
Upper	Reference		–
Middle	0.99 (0.68–1.42)	0.94	–	0.97
Lower	0.77 (0.54–1.09)	0.14	–	0.87
Mixed	1.92 (1.31–2.82)	0.001	–	0.12
Tumour size	1.02 (1.01–1.02)	<0.001	1.01 (1.00–1.01)	0.01
Histologic type
Differentiated	Reference
Undifferentiated	1.28 (0.92–1.78)	0.14
Vascular invasion
Negative	Reference		–
Positive	2.04 (1.58–2.64)	<0.001	–	0.89
Perineural invasion
Negative	Reference		–
Positive	1.85 (1.41–2.42)	<0.001	–	0.14
pT stage
T1	Reference		Reference
T2	2.96 (0.82–10.76)	0.10	3.04 (0.83–11.09)	0.09
T3	7.58 (2.40–24.01)	0.001	4.26 (1.33–13.69)	0.02
T4a	16.87 (5.37–53.01)	<0.001	6.82 (2.11–22.01)	0.001
T4b	21.02 (5.57–79.25)	<0.001	10.31 (2.66–39.88)	0.001
pN stage
N0	Reference		Reference
N1	1.34 (0.71–2.53)	0.37	1.44 (0.76–2.75)	0.26
N2	2.50 (1.43–4.35)	0.001	2.16 (1.24–3.79)	0.01
N3a	5.03 (3.00–8.45)	<0.001	3.56 (2.09–6.06)	<0.001
N3b	9.79 (5.87–16.33)	<0.001	5.84 (3.25–9.93)	<0.001
Adjuvant chemotherapy
No	Reference		Reference
Yes	0.74 (0.57–0.96)	0.02	0.66 (0.51–0.87)	0.003
Number of positive tumour markers before surgery
0	Reference		Reference
1	1.98 (1.50–2.61)	<0.001	1.40 (1.05–1.87)	0.02
2	3.45 (2.17–5.47)	<0.001	1.85 (115–2.97)	<0.001
Number of positive tumour markers after surgery
0	Reference		–
1	1.65 (1.22–2.24)	0.001	–	0.97
2	3.73 (1.83–7.58)	<0.001	–	0.15