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. 2020 May 22;123(3):459–470. doi: 10.1038/s41416-020-0898-3

Fig. 6. Proposed model of interaction between omental adipocytes and GC growth.

Fig. 6

CXCL2 secreted from omental adipocytes activates AKT phosphorylation of gastric cancer cells, which directly promotes gastric cancer growth and motility. In addition, VEGFA in gastric cancer cells is also upregulated through HIF1α upregulation, resulting in angiogenesis. Consequently, gastric cancer cells were transformed to a more aggressive phenotype, which induces peritoneal metastasis thorough recruitment to the omentum itself.