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. 2020 Aug 4;10:13162. doi: 10.1038/s41598-020-70108-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-dependent effects of the A391T variant on regional T2w/T1w ratio. (a) Representative maps of the T2w/T1w ratio in CT and TT carriers overlaid on CC controls where ratio is either increased or decreased with a p value of < 0.05 on a pixel-by-pixel basis via student’s t-test. Heat map corresponds to the direction of change of the T2w/T1w ratio relative to the CC group, with yellow/orange representing an increase and blue representing a decrease. (b) Quantification of ROIs including globus pallidus (GPi), lateral putamen (LPut), and substantia nigra (SN) based on rs13107325 genotype, compared using post-hoc Dunnett’s test. Data points are shown for each individual, with the black horizontal line representing mean for each genotype. CC (white circles) n = 46, CT (gray circles) n = 44, TT (black circles) n = 43.