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. 2020 Aug 4;10:13162. doi: 10.1038/s41598-020-70108-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of plasma protein N-glycans based on rs13107325 genotype. (a) Summary data for the 20 most abundant plasma protein N-glycans sorted by rs13107325 genotype. Data presented as mean +/− standard error of the mean (SEM) for the percent (%) abundance of each N-glycan relative to the total N-glycan pool. Corresponding N-glycan structures are shown above each predicted m/z (mass/charge ratio) including a key for individual monosaccharide components of human N-glycans. (b) Heat map illustrating percent change of each individual glycan in CT and TT relative to CC; scaled from dark blue → white → bright red as − 50.0% → 0% → + 50.0%. Genotypes compared using student’s t-test. Individual N-glycans that are significantly different in CT and TT compared to CC are marked with an asterisk; *p < 0.05. CC (white bars) n = 33, CT (gray bars) n = 31, TT (black bars) n = 25.