TABLE 1.
Representative studies of obesity-related miRNAs in adipocyte-derived EVs.
| Subject of study | Markers in EV | Potential targets/pathways | Roles in development of obesity-associated disease |
| Obese healthy adolescent (Ferrante et al., 2015) | miRNA | TGF-β, Wnt/β-catenin | Induced changes in cellular microenvironment of obese healthy individuals |
| Obese healthy women (Santamaria-Martos et al., 2020) | miRNA | Induced changes in plasma of obese healthy individuals | |
| ADicerKO mice (Thomou et al., 2017) | miRNA | – | Major circulating miRNA source, and regulated distant organs |
| ob/ob mice (Dang et al., 2019) | miR-141-3p | – | Inhibited hepatocyte insulin sensitivity |
| db/db mice (Yu et al., 2018) | miR-27a | PPARγ | Impaired insulin signaling in skeletal muscle |
| Bone marrow-derived macrophages (Zhang et al., 2016) | miR-155 | SOCS1 | Controlled M1 macrophage polarization |
| Macrophages (Pan et al., 2019) | miR-34a | Klf4 | Suppressed M2 polarization |
| Hepatocellular cancer (Liu et al., 2019) | miR-23a/b | VHL/HIF | Promoted cancer cell growth and migration |