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. 2020 May 19;5(8):1172–1179. doi: 10.1016/j.ekir.2020.05.004

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© 2020 International Society of Nephrology. Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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(a) Light microscopy showed glomerular endotheliopathy characterized by endothelial cell swelling. Large arrows: mesangial loosening, arrowhead: swelling of glomerular endothelial cells, small arrow: double contour structure of the GBM. Periodic acid–Schiff staining, original magnification ×400 (case 1); hematoxylin and eosin staining, original magnification ×400 (case 3); Masson trichrome staining, original magnification ×200 (case 4); periodic acid–methenamine silver staining, original magnification ×600 (case 6). Bar = 40 μm. (b) Glomerular tip lesion (arrows). Periodic acid–methenamine silver staining, original magnification ×200. Bar = 40 μm (case 5). (c) Extravasation of erythrocytes (arrowheads), sludging of erythrocytes (arrows). Masson trichrome staining, original magnification ×400. Bar = 30 μm (case 4). (d) Fragmentation of erythrocytes (arrows), Masson trichrome staining, original magnification ×400. Bar = 30 μm (case 5). (e) Massive hyaline degeneration of podocytes (arrows). Masson trichrome staining, original magnification ×600. Bar = 20 μm (case 4). (f) Endothelial cell mitosis (arrow). Periodic acid–methenamine silver staining, original magnification ×600. Bar = 20 μm (case 4). (g) Arteriolar myocyte vacuolization (arrowheads). Periodic acid–methenamine staining, original magnification ×400. Bar = 35 μm (case 6). (h) Arteriolar hyalinosis (arrow). Hematoxylin and eosin staining, original magnification ×400. Bar = 25 μm (case 1). (i) Peritubular capillaritis, including infiltration of eosinophils (arrows). Hematoxylin and eosin staining, original magnification ×400. Bar = 20 μm (case 3).