Table 1.
Clinical data
| Characteristics | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | Case 7 | Median | Min | Max | Normal value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Demographics | |||||||||||
| Sex | Female | Male | Male | Female | Male | Male | Female | ||||
| Age at diagnosis, yr | 80 | 84 | 53 | 60 | 34 | 50 | 38 | 53 | 34 | 84 | |
| Initial symptom | Anasarca | Anasarca, appetite loss | Anasarca, lowering urine output | Anasarca, body weight gain | Anasarca, dyspnea | Anasarca, appetite loss, abdominal swelling | Anasarca, fever, abdominal pain | ||||
| Pleural effusion | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Acites | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Underlying disorders | HT | HT, DM, PMR | HT | no | UC | DM | DM, UC | ||||
| Body weight gain, kg | 13.3 | 26.4 | 22.2 | 8.3 | 23.7 | 26.8 | NA | 22.95 | 8.3 | 26.8 | |
| Blood pressure, mm Hg | 164/80 | 108/79 | 147/91 | 158/100 | 113/77 | 147/88 | 159/98 | 147/88 | 108/77 | 164/98 | |
| Heart rate, beats/min | 97 | 93 | 93 | 85 | 108 | 100 | 130 | 97 | 85 | 130 | |
| Body temperature, °C | 37.5 | 35.9 | 36.9 | 36.9 | 37.8 | 36.8 | 37.4 | 36.9 | 35.9 | 37.8 | |
| Laboratory Test | |||||||||||
| Hb, g/dl | 11.1 | 9.3 | 7.6 | 9.6 | 5.6 | 12.7 | 11.9 | 9.6 | 5.6 | 12.7 | 11.3–15.0 |
| Platelet count (minimum value), 103/μl | 9 | 12 | 21 | 46 | 45 | 28 | 32 | 28 | 9 | 46 | 155–350 |
| Albumin (on admission), g/dl | 2.8 | 2.4 | 2.9 | 3.1 | 1.5 | 2.5 | 2.7 | 2.7 | 1.5 | 3.1 | 4.1–5.1 |
| ALP, IU/l | 1438 | 640 | 570 | 534 | 641 | 1181 | 1179 | 641 | 534 | 1438 | 0.3–11 |
| Total bilirubin, mg/dl | 1.5 | 0.7 | 0.7 | 0.6 | 1.7 | 0.9 | 0.6 | 0.7 | 0.6 | 1.7 | 0.3–1.0 |
| Cre (maximum value), mg/dl | 1.98 | 2.68 | 5 | 1.85 | 6.28 | 2.68 | 5.64 | 2.68 | 1.85 | 6.28 | 0.6–1.0 |
| Na, mEq/l | 136 | 141 | 145 | 138 | 136 | 139 | 137 | 138 | 136 | 145 | 138–145 |
| K, mEq/l | 4.3 | 3.7 | 5.5 | 3.4 | 5.1 | 4.2 | 3.9 | 4.2 | 3.4 | 5.5 | 3.6–4.8 |
| Cl, mEq/l | 106 | 103 | 109 | 100 | 99 | 106 | 104 | 104 | 99 | 109 | 101–108 |
| BNP, pg/ml | 182 | 113.8 | 44.1 | 80.9 | 181.7 | 99.7 | 15.5 | 99.7 | 15.5 | 182 | <18.4 |
| CRP, mg/dl | 7.3 | 8.3 | 14.3 | 2.1 | 12.5 | 11.9 | 21.5 | 11.9 | 2.1 | 21.5 | <0.3 |
| IL-6, ng/l | 21.3 | 12.3 | 17.5 | 1.9 | 6.2 | 3 | 103 | 12.3 | 1.9 | 103 | <4.0 |
| VEGF, pg/ml | 454 | 177 | 58.3 | 48.8 | 552 | 133 | 288 | 177 | 48.8 | 552 | <38 |
| Urine dipstick test | |||||||||||
| Gravity | 1.013 | 1.014 | 1.028 | 1.026 | 1.025 | 1.035 | 1.006 | 1.025 | 1.006 | 1.035 | |
| Urine sedimentation test, /HPF | |||||||||||
| Red blood cell | 10 | 30 | 4 | 100 | Many | 5–9 | <1 | ||||
| Weight blood cell | 1–5 | 11–30 | 1–4 | 1–4 | Many | 5–9 | Many | ||||
| Laboratory data (urine), g/d | |||||||||||
| Urine protein | 0.86 | 0.28 | 0.3 | 3.71 | 0.45 | 0.43 | 0.59 | 0.45 | 0.28 | 3.71 | |
| Diagnosis criteria | |||||||||||
| Thrombocytopenia | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Anasarca | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Fever or elevation of CRP | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Renal insufficiency | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Reticulin fibrosis | No | Yes | Yes | No | Yes | Yes | Yes | ||||
| Organomegaly | Yes | No | Yes | Yes | Yes | Yes | Yes | ||||
| Lymphadenopathy | Yes | Yes | Yes | Yes | Yes | Yes | Yes | ||||
| Lymphadenopathy (histology) | Not sampled | HV | HV | Atypical | HV | Atypical | HV |
ALP, alkaline phosphatase; BNP, brain natriuretic protein; Cre, creatinine; CRP, C-reactive protein; DM, diabetes mellitus; Hb, hemoglobin; HPF, high-power field; HT, hypertension; HV, hyaline vascular type; IL, interleukin; NA, not available; PMR, polymyalgia rheumatica; UC, ulcerative colitis; VEGF, vascular endothelial growth factor.