FIGURE 1.

Schematic representation of the procedures followed to develop a hyperuricemia mouse model. Control mice were fed with a standard diet and were intraperitoneally injected with saline daily. To induce hyperuricemia, mice were fed with food supplemented with 25% yeast polysaccharide (YP) and were intraperitoneally injected with potassium oxonate (PO, 250 mg/kg) daily. Mice in the model group were subjected to intragastrical injections of saline daily. In the treatment groups, mice received intragastrical injections of different concentrations of bergenin. Mice in the positive control group were administered allopurinol (25 mg/kg) daily.