Table 1.
Statistics for berbamine analog dose-response curves for 200 μM neomycin and 100 μM gentamicin for the data shown in Figure 3.
| Compound Name | Neomycin: ANOVA | Neomycin: P-value by concentration (μM) |
Gentamicin: ANOVA | Gentamicin: P-value by concentration (μM) |
|---|---|---|---|---|
| BA-1 |
F(6,69) = 94.79 P < 0.0001 |
0.1; ** 0.32; **** 1; **** |
F(6,70) = 48.91 P < 0.0001 |
0.032; * 0.32; **** 1; **** |
| BA-2 |
F(6,66) = 72.23 P < 0.0001 |
0.0032; ** 0.01; **** 0.032; **** 0.1; **** 0.32; **** 1; **** |
F(8,89) = 50.76 P < 0.0001 |
0.032; **** 0.1; **** 0.32; *** 1; **** 3.16; **** 9.98; **** |
| BA-3 |
F(6,70) = 70.76 P < 0.0001 |
0.032; *** 0.1; **** 0.32; **** 1; **** |
F(8,63) = 61.08 P < 0.0001 |
0.0032; * 0.032; **** 0.1; **** 0.32; **** 1; **** 3.16; **** 9.98; **** |
| BA-4 |
F(6,70) = 51.23 P < 0.0001 |
0.0032; ** 0.01; ** 0.032**** 0.1; **** 0.32; *** 1; **** |
F(6,60) = 19.36 P < 0.0001 |
0.01* 0.032; * 0.1; **** 0.32; **** 1; **** |
| BA-5 |
F(6,68) = 15.29 P < 0.0001 |
0.1; ** 0.32; **** 1; **** |
F(6,42) = 4.34 P = 0.017 |
0.0032; * 1; *** |
| BA-6 |
F(6,70) = 94.12 P < 0.0001 |
0.1; **** 0.32; **** 1; **** |
F(6,76) = 41.35 P < 0.0001 |
0.0032; **** 0.032; *** 0.32; **** 1; **** |
| BA-7 |
F(6,53) = 113.8 P < 0.0001 |
0.032; **** 0.1; **** 0.32; **** 1; **** |
F(8,77) = 10.83 P < 0.0001 |
1; *** 3.16; **** |
| BA-8 |
F(6,72) = 19.58 P < 0.0001 |
0.0032; **** 0.01; **** 0.032; **** |
F(8,59) = 19.85 P < 0.0001 |
0.32; **** 1; **** 3.16; **** |
| BA-9 |
F(4,40) = 332.3 P < 0.0001 |
0.1; **** 1; **** 9.98; **** |
F(4,38) = 32.05 P < 0.0001 |
0.1; * 9.98; * |
| BA-10 |
F(4,39) = 111.5 P < 0.0001 |
0.1; **** 1; **** 9.98; **** |
F(4,33) = 9.09 P < 0.0001 |
ns |
| BA-11 |
F(4,26) = 87.80 P < 0.0001 |
0.1; ** 1; **** 9.98; ** |
F(4,23) = 7.09 P = 0.0007 |
ns |
| BA-12 |
F(4,37) = 5.90 P = 0.0009 |
1; *** |
F(4,52) = 67.35 P < 0.0001 |
0.1; **** 1;**** 9.98**** |
| BA-13 | F(4,32) = 0.60 | Ns | F(4,22) = 5.18 P = 0.004 | 0.1; ** |
| BA-14 | F(4,44) = 0.468 | Ns |
F(4,48) = 10.54 P < 0.0001 |
0.1; *** 1; **** 9.98; *** |
| BA-15 |
F(4,48) = 8.03 P < 0.0001 |
0.1; ** |
F(5,34) = 1.80 P = 0.139 |
ns |
| BA-16 | F(4,40) = 5.99 P = 0.0007 | 1; ** |
F(5,34) = 1.29 P = 0.289 |
ns |
| Berbamine |
F(6,60) = 4.02 P = 0.0019 |
0.32* |
F(6,66) = 2.14 P = 0.06 |
ns |
Compound names in bold indicate protection from both neomycin and gentamicin, while compound names in black (not bold) protect from neomycin or gentamicin, and compound names in gray indicate non-protective compounds. Data were analyzed by one-way ANOVA (columns 2 and 4) followed by Bonferroni-corrected t-tests for multiple comparisons (columns 3 and 5). In columns 3 and 5, numbers in black indicate significant increases in hair cell survival (compared to aminoglycoside-only controls), while numbers in gray indicate significant reductions in hair cell survival relative to aminoglycoside-only groups. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. ns, not significant.