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. 2020 Aug 4;10:13139. doi: 10.1038/s41598-020-70140-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Selection of test drugs and decomposition analysis. (a) List of the candidate drugs and control chemicals. Candidate drugs were selected and listed based on the following criteria: (1) drugs with a moderate score defined as median plus 0.75 times IQR of P14V score distribution, (2) no publications related to ER stress or UPR stress, and (3) drugs approved by FDA for oral use. Three compounds with low absolute values for P14V score (the bottom three compounds) were also selected as predicted negative compounds. (b) Decomposition analysis of each chemical. Radar chart visualizing OLSA outputs of the selected compounds. Direction indicates each vector score. Central black line is the line representing zero score. TPG, thapsigargin; CSP, ciclosporin A; PTP, protriptyline; PPZ, perphenazine; PBZ, phenoxybenzamine; CHD, cyproheptadine; TPM, trimipramine; DSL, delsoline; CPX, ciclopirox; CSE, cycloserine. Vectors are arranged clockwise with the top being P1V. *, P14V.