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. 2020 Aug 4;10:13077. doi: 10.1038/s41598-020-69805-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-17F suppresses expression of β-cell identity genes and glucose stimulated insulin secretion in mouse islets. Min6 cells were stimulated with IL-17F or IL-17A in the presence of TNFα + IFNγ (Cyto) for 24 h and (A) Ins1, (B) Ins2, (C) Glut2, (D) Pdx1 and (E) Foxo1 expression measured by Taqman quantitative RT-PCR (n = 4 for all groups). NOD islets were stimulated with IL-17F or IL-17A in the presence of TNFα + IFNγ (Cyto) for 24 h and (F) Ins1, (G) Ins2, (H) Glut2, (I) Pdx1 and (J) Foxo1 expression measured by Taqman quantitative RT-PCR (n = 6 for all groups), p < 0.05 (*), p < 0.01 (**), p < 0.001 (***) One-Way ANOVA with Bonferonni’s Multiple Comparison test. (K) NOD islets were stimulated with IL-17F or IL-17A in the presence of TNFα + IFNγ (Cyto) for 48 h and glucose stimulated insulin secretion assay performed (3 independent experiments, n = 4 for all groups), p < 0.05 (*), p < 0.01 (**), p < 0.001 (***) Two-Way ANOVA with Bonferonni’s Multiple Comparison test.