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. 2020 Aug 4;10:13077. doi: 10.1038/s41598-020-69805-2

Figure 4.

Figure 4

IL-17F induces cell death in mouse islets. NOD islets were stimulated with IL-17F or IL-17A in the presence of (A,C) TNFα + IFNγ or (B,D) IL-1β + IFNγ for 4 days and cell death quantified by DNA fragmentation (n = 5 for TNFα + IFNγ and n = 2 for IL-1β + IFNγ), p < 0.05 (*), p < 0.001 (***) One-Way ANOVA with Bonferonni’s Multiple Comparison test. (C) C57Bl/6 islets were stimulated with IL-17F or IL-17A in the presence of (C) TNFα + IFNγ or (D) IL-1β + IFNγ for 4 days and cell death quantified by DNA fragmentation (n = 3 for all groups), p < 0.05 (*), p < 0.001 (***) One-Way ANOVA with Bonferonni’s Multiple Comparison test.