Figure 11.

Microtubule Assembly in VD. Microtubule dynamics markers were determined in post-mortem human brain samples from SNpc, Hippocampus and Cortex of VD patients and controls. The levels of acetylated α-tubulin, acetylated tau, phosphor-tau and tau were determined in: (A) SNpc; (B) Hippocampus and (C) Cortex brain tissue homogenates. (D) Densitometric analysis of the levels of acetylated α-tubulin, acetylated tau, phosphor-tau, tau and phosphor-tau/tau. The blots were re-probed for α-tubulin ato confirm equal protein loading Values are mean ± SEM (n = 5–6, *p < 0.05, versus SNpc control subjects and ^##p < 0.01, versus hippocampus control subjects; ^&&p < 0.01, versus cortex control subjects). Full length blots are presented in the Supplementary Information.