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. 2020 Aug 4;10:13115. doi: 10.1038/s41598-020-70102-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-18-driven IFN-γ secretion to T. gondii depends on multiple redundant inflammasomes. (a) Percent of IFN-γ⁺ cells amongst total CD3^–NKp46⁺ cells in the spleen 24 h after i.v. injection of 10⁷ T. gondii ME49 tachyzoites into B6 mice and different mouse strains lacking either Caspase1/11, Nlrp1, Nlrp3 or Nlrp1 and Nlrp3. (b) Serum IL-18 concentrations 24 h after i.v. injection of 10⁷ T. gondii ME49 tachyzoites into B6 mice and different mouse strains lacking either Caspase1/11, Nlrp1, Nlrp3 or Nlrp1 and Nlrp3. Results are presented as individual data points of 3–25 mice per group from at least two pooled independent experiments. Statistical analyses: Two-way ANOVA followed by Tukey’s post hoc test. Significant differences within each mouse genotype are indicated by asterisks: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; n.s. not significant. Further significance values are shown in Tables S1 and S2.