Fig. (3).

Comparison of Mtb Lesions in Humans and Various Small Animal Models. The diversity of granulomas in various animal models of TB is shown. Lesions in rhesus macaques (A) appear histopathologically remarkably analogous to human granulomas consisting of a central area of necrosis with a wall of macrophages surrounded by a cuff of leukocytes. Similar structures also develop in guinea pigs (B). In stark contrast, C57BL/6 mice (C) do not develop highly organized TB lesions, and C3HeB/FeJ mice (D) develop highly suppurative lesions with cavitations more closely resembling abscesses than caseation. Similar to NHP, rabbits (E) develop lesions with cavitation resembling human pathology. (A higher resolution/colour version of this figure is available in the electronic copy of the article).