Table 2.

Clinical characteristics of breast cancer patients according to age

Risk factor		NOD2 < 50 years (n = 68)		Control group < 50 years (n = 141)		OR	p	NOD2 ≥ 50 years (n = 82)		Control group ≥ 50 years (n = 235)		OR	p
		n	%	n	%			n	%	n	%
Age median (range)		42.8 years (25.5–49.9)		43.8 years (26.4–50.0)			0.331*	58.2 years (50.0–80.7)		59.3 years (50.0–78.3)			0.928*
Menopausal status
	Premenopausal	61	89.7	129	91.5	0.81	0.798	13	15.9	31	13.2	1.24	0.678
	Postmenopausal	7	10.3	12	8.5	1.0		69	83.1	204	86.8	1.0
Co-morbid condition
	Yes	17	25.0	46	32.6	0.69	0.335	53	64.6	139	59.1	1.26	0.457
	No	51	75.0	95	67.4	1.0		29	35.4	96	40.9	1.0
Diabetes
	Yes	2	2.9	2	1.4	2.11	0.597	4	4.9	13	5.5	0.88	1.00
	No	66	97.1	139	98.6	1.0		78	95.1	222	94.5	1.0
Cardiovascular diseases
	Yes	2	2.9	1	0.7	4.24	0.248	9	11.0	38	16.2	0.64	0.284
	No	66	97.1	140	99.3	1.0		73	89.0	197	83.8	1.0
Viral diseases
	Yes	0	0.0	5	3.5	0.0	0.176	3	3.7	13	5.5	0.65	0.770
	No	68	100	136	96.5	1.0		79	96.3	222	94.5	1.0
Cancer in family history
	Yes	41	60.3	83	58.9	1.06	0.963	53	64.6	123	52.3	1.66	0.072
	No	27	39.7	58	41.1	1.0		29	35.4	112	47.7	1.0
Breast cancer in family history
	Yes	17	25.0	27	19.1	1.41	0.429	26	31.7	35	14.9	2.65	0.002
	No	51	75.0	114	80.9	1.0		56	68.3	200	85.1	1.0
Lung cancer in family history
	Yes	6	8.8	13	9.2	0.95	0.870	6	7.3	21	8.9	0.80	0.819
	No	62	91.2	128	90.8	1.0		76	92.7	214	91.1	1.0
Gynaecological cancer in family history
	Yes	7	10.3	12	8.5	1.23	0.870	10	12.2	25	10.6	1.17	0.855
	No	61	89.7	129	91.5	1.0		72	87.8	210	89.4	1.0
Stomach cancer in family history
	Yes	6	8.8	12	8.5	1.04	0.851	8	9.8	14	6.0	1.71	0.361
	No	62	91.2	129	91.5	1.0		74	90.2	221	94.0	1.0
Pancreas cancer in family history
	Yes	4	5.9	2	1.4	4.34	0.089	2	2.4	4	1.7	1.44	0.651
	No	64	94.1	139	98.6	1.0		80	97.6	231	98.3	1.0
Bowel cancer
	Yes	10	14.7	8	5.7	2.87	0.037	9	11.0	25	10.6	1.04	0.903
	No	58	85.3	133	94.3	1.0		73	89.0	210	89.4	1.0

^*Mann-Whitney U test