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. 2020 May 5;11(3):e00810-20. doi: 10.1128/mBio.00810-20

FIG 1.

FIG 1

Alignment and characteristics of UL11 homolog sequences. (A) Sequences of UL11 homologs from herpesviruses aligned to HSV-1 UL11 with HSV-1 residue numbers marked. Human virus sequences used include HSV-1 strain 17 UL11 (RefSeq accession no. YP_009137085.1), HSV-2 strain HG52 UL11 (RefSeq YP_009137162.1), VZV strain Dumas ORF49 (RefSeq NP_040171.1), EBV strain B95-8 BBLF1 (RefSeq YP_401686.1), CMV strain AD169 UL99 (RefSeq P13200.3), HHV-6A strain Uganda-1102 U71 (RefSeq NP_042964.1), HHV-6B strain Z29 U71 (RefSeq NP_050250.1), HHV-7 strain JI U71 (RefSeq YP_073811.1), and KSHV strain GK18 ORF38 (RefSeq YP_001129391.1). Other representative animal virus sequences used include Marek’s disease virus (MDV) strain Md5 UL11 (RefSeq YP_001033939.1), pseudorabies virus (PRV) composite strain UL11 (RefSeq YP_068364.1), murine cytomegalovirus (MCMV) strain Smith UL99 (RefSeq YP_214100.1), saimiriine herpesvirus 2 (SaHV-2) ORF38 (RefSeq NP_040240.1), and equine herpesvirus 2 (EHV-2) strain 86/67 myristoylated tegument protein (RefSeq NP_042635.1). All sequences show the NCBI reference sequence accession number or code in parentheses. Conserved residues are marked with an asterisk. Myristoylated glycines and palmitoylated cysteines, experimentally determined or predicted, are shown in italicized type in cyan text. Acidic clusters, experimentally defined or predicted, are boxed in red. Groups of basic residues are boxed in blue. Beta strands and alpha helices predicted by PSIPRED (http://bioinf.cs.ucl.ac.uk/psipred/) are highlighted in yellow and light teal, respectively. Disorder-promoting residues (A/G/S/P/Q/E/R/K) are colored in magenta. Residues predicted to be disordered by DISOPRED3 (http://bioinf.cs.ucl.ac.uk/psipred/) are underlined in gray. (B) Representation of disorder by residue in HSV-1 UL11 as predicted by FoldUnfold (http://bioinfo.protres.ru/ogu/). Residues predicted to be in natively folded regions are shown in blue, and residues predicted to be in unfolded regions are shown in red. Residues scoring below the threshold (black line) but surrounded by folded residues are to be treated as folded and are shown in cyan.