Table 1.
Comparison general characteristics, clinical, and laboratory parameters of participants according to MC4R rs17782313 genotypes
| Women | Men | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| TT | TC | CC | P* | TT | TC | CC | P* | ||
| Age (year) | 38.46 (8.95) | 39.07 (8.32) | 36.31 (8.54) | 0.628 | 39.21 (6.75) | 37.26 (6.07) | 40.44 (3.64) | 0.527 | |
| WC | 103.06 (10.43) | 105.33 (9.31) | 101.14 (7.14) | 0.439 | 113.54 (5.89) | 113.57 (7.45) | 112.56 (5.20) | 0.651 | |
| BMI (kg/m2) | 35.02 (4.25) | 35.27 (3.41) | 34.99 (3.80) | 0.990 | 33.90 (2.45) | 33.55 (2.85) | 33.64 (2.53) | 0.622 | |
| Physical activity level (%) | 0.129 | 0.778 | |||||||
| Low | 33.3 | 42.9 | 23.8 | 51.7 | 34.5 | 13.8 | |||
| Moderate | 26.7 | 46.6 | 26.7 | 44.4 | 44.4 | 11.2 | |||
| High | 66.7 | 20.0 | 13.3 | 54.6 | 22.7 | 22.7 | |||
| Marital status (%) | 0.883 | 0.827 | |||||||
| Married | 36.7 | 36.7 | 22.6 | 49.1 | 35.6 | 15.3 | |||
| Single | 40.0 | 40.0 | 20.0 | 60.0 | 20.0 | 20.0 | |||
| SES (%) | |||||||||
| Low | 0 | 50.0 | 50.0 | 0.024 | 0 | 0 | 0 | 0.904 | |
| Middle | 37.0 | 38.9 | 24.1 | 59.1 | 18.2 | 22.7 | |||
| High | 57.2 | 35.7 | 7.1 | 46.8 | 40.4 | 12.8 | |||
| Depressing (%) | 0.503 | 0.439 | |||||||
| Normal | 45.8 | 37.5 | 16.7 | 48.7 | 30.8 | 20.5 | |||
| Mild | 18.2 | 54.5 | 27.3 | 45.5 | 54.5 | 0.0 | |||
| Moderate | 33.3 | 23.8 | 42.9 | 53.8 | 30.8 | 15.4 | |||
| Severe | 42.8 | 28.6 | 28.6 | 66.7 | 0.0 | 33.3 | |||
| Extremely severe | 22.2 | 66.7 | 11.1 | 66.7 | 33.3 | 0.0 | |||
| Anxiety (%) | 0.550 | 0.909 | |||||||
| Normal | 40.0 | 45.0 | 15.0 | 48.4 | 35.5 | 16.1 | |||
| Mild | 50.0 | 37.5 | 12.5 | 40.0 | 40.0 | 20.0 | |||
| Moderate | 33.3 | 38.9 | 27.8 | 61.1 | 33.3 | 5.6 | |||
| Severe | 37.5 | 25.0 | 37.5 | 50.0 | 25.0 | 25.0 | |||
| Extremely severe | 38.9 | 38.9 | 22.2 | 42.8 | 28.6 | 28.6 | |||
| Stress (%) | 0.275 | 0.602 | |||||||
| Normal | 34.8 | 43.5 | 21.7 | 50.0 | 35.3 | 14.7 | |||
| Mild | 30.8 | 30.8 | 38.4 | 41.7 | 33.3 | 25.0 | |||
| Moderate | 42.9 | 38.1 | 19.0 | 50.0 | 35.7 | 14.3 | |||
| Severe | 38.5 | 46.1 | 15.4 | 80.0 | 0.0 | 20.0 | |||
| Extremely severe | 100.0 | 0.0 | 0.0 | 50.0 | 50.0 | 0.0 | |||
| Appetite | 32.39 (9.49) | 31.89 (6.80) | 33.75 (7.62) | 0.783 | 34.21 (10.75) | 34.70 (10.00) | 35.78 (7.93) | 0.880 | |
| LDL-C (mg/dl) | 126.9 (29.6) | 118.56 (31.06) | 108.91 (28.09) | 0.161 | 121.48 (25.94) | 118.30 (30.01) | 117.58 (22.48) | 0.471 | |
| HDL (mg/dl) | 48.46 (10.27) | 46.37 (10.19) | 49.44 (6.46) | 0.549 | 40.91 (6.79) | 43.35 (9.22) | 45.00 (10.46) | 0.388 | |
| Cholesterol (mg/dl) | 197.71 (33.88) | 185.74 (35.45) | 177.75 (28.62) | 0.146 | 188.88 (28.64) | 187.78 (31.20) | 193.56 (28.58) | 0.918 | |
| TG (mg/dl) | 98.5 (77.75, 141.00) | 93.00 (76.00, 125.00) | 98.50 (73.25, 109.75) | 0.638 | 120.00 (78.00, 168.50) | 121.00 (90.00, 164.00) | 123.00 (93.00, 176.50) | 0.869 | |
| AIP | − 0.02 (0.24) | − 0.03 (0.23) | − .09 (0.17) | 0.631 | 0.11 (0.26) | 0.09 (0.25) | 0.12 (0.29) | 0.907 | |
| Glucose (mg/dl) | 92.00 (85.25, 95.00) | 91.00 (81.00, 101.00) | 90.00 (85.25, 94.00) | 0.834 | 93.00 (87.00, 101.50) | 90.00 (83.00, 97.00) | 101.00 (89.00, 159.50) | 0.040 | |
| Insulin, U/ml | 13.55 (9.28, 24.10) | 19.60 (9.70, 27.30) | 13.75 (9.00, 16.23) | 0.306 | 11.40 (8.35, 17.70) | 10.90 (8.40, 19.50) | 11.00 (9.75, 25.80) | 0.507 | |
| HOMA-IR | 3.17 (2.00, 5.56) | 4.82 (2.01, 6.58) | 3.15 (2.09, 3.86) | 0.409 | 2.70 (1.76, 4.06) | 2.61 (1.87, 5.04) | 4.16 (2.75, 6.99) | 0.077 | |
| QUICKI | 0.32 (0.03) | 0.32 (0.04) | 0.33 (0.03) | 0.466 | 0.33 (0.03) | 0.33 (0.03) | 0.31 (0.03) | 0.126 | |
| SBP (mmHg) | 111.86 (14.48) | 117.26 (16.85) | 111.19 (14.40) | 0.404 | 116.67 (11.43) | 118.70 (15.83) | 116.67 (14.14) | 0.816 | |
| DBP (mmHg) | 76.50 (10.11) | 79.15 (14.55) | 75.50 (11.68) | 0.644 | 76.51 (10.86) | 78.26 (10.93) | 75.56 (12.10) | 0.584 | |
| α-MSH (ng/l) | 2.16 (2.12–2.20) | 2.26 (2.17–2.36) | 2.26 (2.11–2.41) | 0.153 | 2.29 (2.20–2.37) | 2.39 (2.25–2.52) | 2.18 (2.09–2.27) | 0.105 | |
| AgRP (pg/ml) | 1.33 (1.29–1.37) | 1.44 (1.36–1.51) | 1.41 (1.29–1.53) | 0.082 | 1.49 (1.42–1.57) | 1.57 (1.46–1.68) | 1.33 (1.25–1.41) | 0.025 | |
Data are presented as mean (SD) or median (25 and 75 percentiles)
BMI body mass index, WC waist circumference, SES socio-economic status, HOMA-IR homeostasis model assessment of insulin resistance, LDL-C low density lipoprotein cholesterol, HDL high-density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, TG triglyceride, QUICKI quantitative insulin sensitivity check index, AgRP agouti-related protein, α-MSH alpha melanocyte stimulating hormone, AIP atherogenic index of plasma
*Analysis of variance for continuous variables and χ2 test for categorical variables