TABLE 2.
Intercept and slope effects across diagnosis at last follow‐up, strata of education, sex, CDR score, and APOE e4 status
| Semantic fluency | Letter fluency | ||||
|---|---|---|---|---|---|
| Intercept (SE) | Slope (SE) 1 | Intercept (SE) | Slope (SE) 1 | ||
| Diagnosis | No MCI | −.126 (.130) | −.027 (.028) | −.668 (.135) | −.008 (.027) |
| aMCI | −.735 (.116) | −.113 (.026)*** | −1.043 (.126) | .015 (.026) | |
| naMCI | −.383 (.122) | −.034 (.025) | −.765 (.132) | −.027 (.024) | |
| Dementia | −1.047 (.220) | −.288 (.085)*** | −.844 (.236) | −.101 (.100) | |
| Education | Low | −.285 (.175) | .040 (.039) | −0.673 (.195) | .025 (.038) |
| Middle | −.175 (.092) | −.068 (.021)** | −.452 (.094) | .018 (.021) | |
| High | −.057 (.096) | −.039 (.024) | −.023 (.093) | −.018 (.023) | |
| Sex | Men | −.423 (.069) | −.038 (.024) | −.672 (.069) | .007 (.023) |
| Women | −.612 (.047) | −.046 (.019)* | −.617 (.048) | < −.001 (.018) | |
| CDR score | 0 | −.371 (.094) | −.017 (.023) | −.710 (.098) | −.029 (.022) |
| .5 | −.688 (.086) | −.064 (.023)** | −.911 (.086) | .026 (.021) | |
| APOE status | e4− | −.645 (.090) | −.029 (.018) | −.946 (.090) | .008 (.017) |
| e4+ | −.789 (.139) | −.084 (.028)** | −.917 (.140) | −.017 (.028) | |
Note. 1Significance of slope effects: * P < .05, ** P < .01, *** P < .001. Models are adjusted for age at baseline, age at baseline x time in study, sex, and education—unless sex or education was used to stratify—and models of letter fluency were additionally adjusted for time in study x time in study
Abbreviations: aMCI, amnestic MCI; APOE, apolipoprotein E; CDR, Clinical Dementia Rating; ICC, intraclass correlation coefficient; I‐S Corr, intercept‐slope correlation; MCI, mild cognitive impairment; naMCI, non‐amnestic MCI; SE, standard error.