Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

letter

. 2020 Jun 16;10(2):e98. doi: 10.1002/ctm2.98

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

graphic file with name CTM2-10-e98-g001.jpg — Association of cell cycle activity with anti‐tumor immune signatures in pan‐cancer and in individual cancer types. A, Association of CCA with CD8+ T cell infiltration levels and immune cytolytic activity. Pearson's correlation test R and FDR are shown. CCA, cell cycle activity. It also applies to following figures. B, Comparison of the ratios of immune‐stimulatory to immune‐inhibitory signatures between higher‐ and lower‐CCA tumors. The Mann‐Whitney U test one‐sided FDR are indicated. The higher‐ and lower‐CCA tumors are the tumors whose CCA scores lie in the upper and bottom third, respectively. A ratio is the log2‐transformed ratio of the geometric mean expression level of all marker genes of an immune‐stimulatory signature to that of an immune‐inhibitory signature in a tumor sample. C, Association of CCA with the expression levels of human leukocyte antigen (HLA) genes. D, Immune‐related pathways which are highly enriched in higher‐CCA tumors in at least 5 individual cancer types identified by KEGG. E, Association of the expression of cell cycle pathway genes with anti‐tumor immune signatures. Pearson's correlation R values are indicated. FDR: false discovery rate, is the adjusted P values computed by the Benjamini and Hochberg method (*, FDR < 0.05; **, FDR < 0.01; ***, FDR < 0.001).

graphic file with name CTM2-10-e98-g002.jpg — Association of cell cycle activity with anti‐tumor immune signatures in pan‐cancer and in individual cancer types. A, Association of CCA with CD8+ T cell infiltration levels and immune cytolytic activity. Pearson's correlation test R and FDR are shown. CCA, cell cycle activity. It also applies to following figures. B, Comparison of the ratios of immune‐stimulatory to immune‐inhibitory signatures between higher‐ and lower‐CCA tumors. The Mann‐Whitney U test one‐sided FDR are indicated. The higher‐ and lower‐CCA tumors are the tumors whose CCA scores lie in the upper and bottom third, respectively. A ratio is the log2‐transformed ratio of the geometric mean expression level of all marker genes of an immune‐stimulatory signature to that of an immune‐inhibitory signature in a tumor sample. C, Association of CCA with the expression levels of human leukocyte antigen (HLA) genes. D, Immune‐related pathways which are highly enriched in higher‐CCA tumors in at least 5 individual cancer types identified by KEGG. E, Association of the expression of cell cycle pathway genes with anti‐tumor immune signatures. Pearson's correlation R values are indicated. FDR: false discovery rate, is the adjusted P values computed by the Benjamini and Hochberg method (*, FDR < 0.05; **, FDR < 0.01; ***, FDR < 0.001).