Increased Expression of LGR6 in TNBC
(A) LGR6 expression in normal mammary cell lines, non-TNBC cell lines, and TNBC cell lines was tested by quantitative real-time PCR. ∗p < 0.05, p < 0.01. (B) The relative expression levels of LGR6 were tested by quantitative real-time PCR in 36 pairs of TNBC specimens. (C) IHC staining of LGR6 and Ki67 expression in two pairs of matched TNBC tumor and adjacent nontumor samples. Original magnification, ×200. (D) Kaplan-Meier analysis showed high expression of LGR6 correlated with poor disease-free survival and overall survival.