Table 1.
Summary of stimuli-responsive zwitterionic DDSs.
| Category | Polyampholytes | Working morphology | Loaded drugs | Special properties | Ref. |
|---|---|---|---|---|---|
| PC | PMB | micelles | PTX | – | [33] |
| PMPC-PDPA | micelles/vesicles | PTX/DOX | pH-responsive | [61], [63] | |
| NAcHis-PCCs | NPs | quercetin | pH-responsive | [73] | |
| PMPC-PLA | vesicles | DOX/DOX·HCl | pH-responsive | [85] | |
| PMPC-Blink-CPLA | micelles | PTX | pH-responsive | [86] | |
| PLL-PMPC(DOX) | micelles | DOX | pH-responsive | [87] | |
| PMPC-PCL | micelles | DOX | – | [104] | |
| PMPC-6sPCL | micelles | PTX | – | [105] | |
| PMPC-ss-PCL | micelles | DOX | redox-responsive | [106] | |
| PMPC-TMZ | micelles | TMZ | redox-responsive | [115] | |
| FA-MPC-DPA | micelles | tamoxifen, PTX | pH-responsive tumor-targeting | [136] | |
| FAMEG-MPC-PCL | micelles | DOX | tumor-targeting | [140] | |
| SB | SSO | micelles | DOX | – | [39] |
| PSBMA-PDEA-PCL | micelles | CUR | pH-responsive | [68] | |
| PSBMA | nanogels | DOX | redox-responsive | [110] | |
| PCL-ss-PDEASB | micelles | DOX | pH- and redox-responsive | [119] | |
| PSBMA-PDPA | micelles | CUR | pH- and thermo-responsive | [127] | |
| CB | PCBMA-ss-PCL-ss-PCBMA | micelles | DOX | redox-responsive | [108] |
| PCBMA-PMAEL | micelles | DOX | redox-responsive | [111] | |
| PCBMA(DC-C) | NPs | DOX·HCl | pH- and redox-responsive | [120] | |
| P(CBMA-DMAEMA)@ZnO | NPs | DOX | pH-responsive | [122] | |
| cRGD-PCSSL | NPs | DOX | redox-responsive tumor-targeting | [145] | |
| cRGD-PCSSD | NPs | DOX | pH-, redox-responsive tumor-targeting | [152] | |
| Poly(AAs) and polypeptides | HHG2C18-L | liposomes | coumari6/temsirolimus | pH-responsive | [75], [77] |
| P(Lys-alt-N, N′-bis(acryloyl) diaminohexane) | micelles | DOX | pH-responsive | [76] | |
| M-HHG2C18-L | NPs | Erlotinib/DOX | pH-responsive | [79] | |
| PALHy-hyd-DOX | micelles | DOX | pH-responsive | [92] | |
| P(lysine methacrylate) | micelles | CPT | redox-responsive | [116] | |
| cRGD-PMIX | vesicles | DOX | pH-responsive tumor-targeting | [146] | |
| Mix-charged zwitterions | CPMA | micelles | DOX | pH-responsive | [50] |
| MSN-HA-SiO2-TSA/DMA | NPs | DOX | pH-, redox-and HAase-responsive | [51] | |
| Z-MSN | NPs | DOX | pH-responsive | [52] | |
| MCM-41 | NPs | LEVO | pH-responsive | [81] | |
| dHAD | micelles | DOX | pH-responsive tumor-targeting | [155] |