Figure 5.

Characterization of the Skeletal Muscle Histopathology

(A) Representative hematoxylin and eosin staining photomicrographs of the quadriceps from untreated BL6, untreated mdx4cv, and AAV-injected mdx4cv mice. TT, AAV made with the transient transfection method; HSV, AAV made with the herpes simplex virus system. (B) Quantification of myofibers with centrally localized myonuclei in the extensor digitorum longus (EDL), diaphragm, quadriceps, and tibialis anterior (TA) from mdx4cv mice injected with the TT method vectors and the HSV method vectors. ∗Significantly different from other dose groups. Data are presented as mean ± standard error of the mean. The difference was considered significant when p < 0.05.