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. 2020 Jul 9;18:664–678. doi: 10.1016/j.omtm.2020.07.004

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Toxicity Assessment

(A) Weekly body weight of AAV-injected mdx4cv mice. TT, AAV made with the transient transfection method; HSV, AAV made with the herpes simplex virus system. (B) Blood chemistry. BUN, blood urea nitrogen; GLDH, glutamate dehydrogenase. ∗Significantly different from other dose groups. (C) Representative photomicrographs of hematoxylin and eosin staining of the liver from untreated BL6, untreated mdx4cv, and AAV injected mdx4cv mice. TT, AAV made with the transient transfection method; HSV, AAV made with the herpes simplex virus system. Data are presented as mean ± standard error of the mean. The difference was considered significant when p < 0.05.