Table 1.
Summary of Experimental Mice
| Strain | Treatment Group | AAV Production Method | Sample Size (n) | Age at Injection (m) | Body Weight at Injection (g) | Dose (vg/Mouse) | Dose (vg/kg) | Age at Termination (m) | Study Duration (m) |
|---|---|---|---|---|---|---|---|---|---|
| BL6 | untreated | N/A | 3 | N/A | N/A | N/A | N/A | 5.00 ± 0.00 | N/A |
| mdx4cv | N/A | 7 | N/A | N/A | N/A | N/A | 5.43 ± 0.46 | N/A | |
| mdx4cv | high | TT | 3 | 1.83 ± 0.00 | 19.17 ± 0.83 | 1.00E+13 | 5.24E+14 | 5.17 ± 0.00 | 3.34 |
| HSV | 3 | 1.67 ± 0.00 | 18.20 ± 0.26 | 5.50E+14 | 5.19 ± 0.01 | 3.52 | |||
| medium | TT | 6 | 1.71 ± 0.04 | 19.15 ± 0.20 | 1.00E+12 | 5.22E+13 | 5.07 ± 0.04 | 3.36 | |
| HSV | 6 | 1.66 ± 0.01 | 19.07 ± 0.82 | 5.30E+13 | 5.20 ± 0.00 | 3.54 | |||
| low | TT | 3 | 2.03 ± 0.07 | 19.37 ± 0.74 | 1.00E+11 | 5.18E+12 | 5.60 ± 0.00 | 3.57 | |
| HSV | 3 | 1.90 ± 0.00 | 20.47 ± 0.95 | 4.91E+12 | 5.67 ± 0.00 | 3.77 |
Data are presented as mean ± standard error of the mean. N/A, not applicable; TT, AAV made with the transient transfection method; HSV, AAV made with the herpes simplex virus system.