Figure 4. Primary, Secondary, and Nonprespecified and Post Hoc Outcomes.

To convert 25-hydroxyvitamin D to nmol/L, multiply by 2.5. The analyses were not adjusted for multiple comparisons. MET indicates metabolic equivalent task; VITAL-DEP, Vitamin D and Omega-3 Trial-Depression Endpoint Prevention.

^aCalculated using Cox regression models that were controlled for age, sex, and fish oil group. For the subgroup analyses, the interactions were tested using multiplicative interaction terms.

^bSum of incidence and recurrence of depression or clinically relevant depressive symptoms.

^cAmong the 16 657 participants without a history of depression at baseline.

^dAmong the 1696 participants with a history of depression at baseline who were not receiving treatment within the past 2 years.

^eIncludes Hispanic, Asian/Pacific Islander, Native American/Alaskan Native, and other or multiple or unspecified race/ethnicity.

^fRestricted to 800 IU/d or less from all sources combined (individual supplements and multivitamins).

^gCalculated as weight in kilograms divided by height in meters squared.