Table 3. Genotype distribution of TLR2, TLR4 and TOLLIP in the two populations.
| Han population | Tibetan population | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene/SNPs | Case (%), n=636 | Control (%), n=608 | P* | OR* (95% CI) | Case (%), n=613 | Control (%), n=603 | P* | OR* (95% CI) | |
| TLR2 | |||||||||
| rs1898830 | Genotype | ||||||||
| AA | 227 (25.9) | 188 (31.1) | 191 (31.2) | 152 (25.2) | |||||
| GA | 297 (47.0) | 292 (48.3) | 0.193 | 0.85 (0.66–1.09) | 279 (45.5) | 316 (52.4) | 0.009 | 0.70 (0.54–0.92) | |
| GG | 108 (17.7) | 125 (20.7) | 0.042 | 0.72 (0.52–0.99) | 143 (23.3) | 135 (22.4) | 0.307 | 0.85 (0.62–1.17) | |
| Allele | |||||||||
| A | 751 (59.4) | 668 (55.2) | 661 (53.9) | 620 (51.4) | |||||
| G | 513 (40.6) | 542 (44.8) | 0.035 | 0.84 (0.72–0.99) | 565 (46.1) | 586 (48.6) | 0.229 | 0.91 (0.77–1.06) | |
| rs3804099 | Genotype | ||||||||
| TT | 313 (49.5) | 294 (48.6) | 374 (61.0) | 357 (59.3) | |||||
| CT | 255 (40.3) | 260 (43.0) | 0.505 | 0.92 (0.73–1.17) | 203 (33.1) | 219 (36.4) | 0.291 | 0.88 (0.69–1.12) | |
| CC | 64 (10.1) | 51 (8.4) | 0.457 | 1.17 (0.78–1.74) | 36 (5.9) | 26 (4.3) | 0.302 | 1.32 (0.78–2.23) | |
| Allele | |||||||||
| T | 881 (69.7) | 848 (70.1) | 951 (77.6) | 933 (77.5) | |||||
| C | 383 (30.3) | 362 (29.9) | 0.826 | 1.02 (0.86–1.21) | 275 (22.4) | 271 (22.5) | 0.951 | 0.99 (0.82–1.20) | |
| rs3804100 | Genotype | ||||||||
| TT | 331 (52.6) | 330 (54.6) | 387 (63.1) | 381 (63.2) | |||||
| CT | 247 (39.3) | 234 (38.7) | 0.654 | 1.06 (0.83–1.34) | 196 (32.0) | 198 (32.8) | 0.804 | 0.97 (0.76–1.24) | |
| CC | 51 (8.1) | 40 (6.6) | 0.241 | 1.30 (0.84–2.00) | 30 (4.9) | 24 (4.0) | 0.501 | 1.21 (0.69–2.11) | |
| Allele | |||||||||
| T | 909 (72.3) | 894 (74.0) | 970 (79.1) | 960 (79.6) | |||||
| C | 349 (27.7) | 314 (26.0) | 0.267 | 1.11 (0.93–1.32) | 256 (20.9) | 246 (20.4) | 0.785 | 1.03 (0.84–1.25) | |
| rs5743708 | Genotype | ||||||||
| GG | 629 (99.7) | 605 (1.0) | 613 (1.0) | 601 (99.7) | |||||
| GA | 2 (0.3) | 0 (0.0) | - | 0 (0.0) | 2 (0.3) | - | |||
| AA | 0 (0.0) | 0 (0.0) | - | 0 (0.0) | 0 (0.0) | - | |||
| Allele | |||||||||
| G | 1260 (99.8) | 1210 (1.0) | 1226 (1.0) | 1204 (99.8) | |||||
| A | 2 (0.2) | 0 (0.0) | - | 0 (0.0) | 2 (0.2) | - | |||
| TLR4 | |||||||||
| rs10759932 | Genotype | ||||||||
| TT | 347 (54.9) | 322 (53.2) | 256 (41.8) | 278 (46.1) | |||||
| CT | 238 (37.7) | 232 (38.3) | 0.628 | 0.94 (0.74–1.20) | 277 (45.2) | 258 (42.8) | 0.193 | 1.17 (0.92–1.49) | |
| CC | 47 (7.4) | 51 (8.4) | 0.499 | 0.46 (0.57–1.32) | 80 (13.1) | 67 (11.1) | 0.176 | 1.29 (0.89–1.86) | |
| Allele | |||||||||
| T | 932 (73.7) | 876 (72.4) | 789 (64.4) | 814 (67.5) | |||||
| C | 332 (26.3) | 334 (27.6) | 0.433 | 0.93 (0.78–1.11) | 437 (35.6) | 392 (32.5) | 0.098 | 1.15 (0.97–1.36) | |
| rs12377632 | Genotype | ||||||||
| CC | 232 (36.7) | 227 (37.5) | 178 (29.0) | 188 (31.2) | |||||
| CT | 304 (48.1) | 288 (47.6) | 0.808 | 1.03 (0.81–1.31) | 316 (51.5) | 304 (50.4) | 0.473 | 1.10 (0.85–1.42) | |
| TT | 96 (15.2) | 90 (14.9) | 0.797 | 1.05 (0.74–1.47) | 119 (19.4) | 111 (18.4) | 0.460 | 1.13 (0.81–1.58) | |
| Allele | |||||||||
| C | 768 (60.8) | 742 (61.3) | 672 (54.8) | 680 (56.4) | |||||
| T | 496 (39.2) | 468 (38.7) | 0.785 | 1.02 (0.87–1.20) | 554 (45.2) | 526 (43.6) | 0.429 | 1.07 (0.91–1.25) | |
| rs11536889 | Genotype | ||||||||
| GG | 361 (57.1) | 339 (56.0) | 436 (71.1) | 387 (64.3) | |||||
| GC | 232 (36.7) | 221 (36.5) | 0.911 | 0.99 (0.78–1.25) | 164 (26.8) | 195 (32.4) | 0.021 | 0.75 (0.58–0.96) | |
| CC | 39 (6.2) | 45 (7.4) | 0.358 | 0.81 (0.51–1.27) | 13 (2.1) | 20 (3.3) | 0.129 | 0.58 (0.28–1.18) | |
| Allele | |||||||||
| G | 954 (75.5) | 899 (74.3) | 1036 (84.5) | 969 (80.5) | |||||
| C | 310 (24.5) | 211 (25.7) | 0.492 | 0.84 (0.78–1.13) | 190 (15.5) | 235 (19.5) | 0.009 | 0.76 (0.61–0.93) | |
| rs7873784 | Genotype | ||||||||
| GG | 523 (82.8) | 508 (84.0) | 534 (87.1) | 516 (85.6) | |||||
| GC | 105 (16.6) | 92 (15.2) | 0.498 | 1.11 (0.82–1.51) | 77 (12.6) | 82 (13.6) | 0.571 | 0.91 (0.6–1.27) | |
| CC | 4 (0.6) | 5 (0.8) | 0.701 | 0.77 (0.21–2.90) | 2(0.3) | 5(0.8) | 0.280 | 0.40 (0.08–2.10) | |
| Allele | |||||||||
| G | 1151 (91.1) | 1108 (91.6) | 1145 (93.4) | 1114 (92.4) | |||||
| C | 113 (8.9) | 102 (8.4) | 0.638 | 1.07 (0.81–1.42) | 81 (6.6) | 92 (7.6) | 0.335 | 0.86 (0.63–1.17) | |
| TOLLIP | |||||||||
| rs3750920 | Genotype | ||||||||
| CC | 294 (46.5) | 288 (47.6) | 310 (50.6) | 303 (50.2) | |||||
| CT | 286 (45.3) | 253 (41.8) | 0.406 | 1.11 (0.87–1.40) | 256 (41.8) | 233 (38.6) | 0.556 | 1.07(0.85–1.36) | |
| TT | 52 (8.2) | 64 (10.6) | 0.279 | 0.80 (0.54–1.20) | 47 (7.7) | 67 (11.1) | 0.065 | 0.68 (0.45–1.02) | |
| Allele | |||||||||
| C | 874 (69.1) | 829 (68.5) | 876 (71.5) | 839 (69.6) | |||||
| T | 390 (30.9) | 381 (31.5) | 0.711 | 0.97 (0.82–1.15) | 350 (28.5) | 367 (30.4) | 0.302 | 0.91 (0.77–1.09) | |
| rs5743899 | Genotype | ||||||||
| TT | 248 (39.2) | 241 (39.8) | 249 (40.6) | 241 (40.0) | |||||
| CT | 291 (46.0) | 276 (45.6) | 0.850 | 1.02 (0.80–1.30) | 280 (45.7) | 275 (45.7) | 0.912 | 0.99 (0.77–1.26) | |
| CC | 93 (14.7) | 88 (14.5) | 0.873 | 1.03 (0.73–1.45) | 84 (13.7) | 86 (14.3) | 0.748 | 0.94 (0.97–1.40) | |
| Allele | |||||||||
| T | 787 (62.3) | 758 (62.6) | 778 (63.5) | 757 (62.9) | |||||
| C | 477 (37.7) | 452 (37.4) | 0.834 | 1.02 (0.87–1.20) | 448 (36.5) | 447 (37.1) | 0.764 | 0.98 (0.83–1.15) | |
| rs5743867 | Genotype | ||||||||
| AA | 254 (40.2) | 249 (41.2) | 256 (41.8) | 249 (41.3) | |||||
| GA | 289 (45.7) | 270 (44.6) | 0.698 | 1.05 (0.8–1.34) | 278 (45.4) | 271 (44.9) | 0.985 | 0.99 (0.78–1.27) | |
| GG | 89 (14.1) | 86 (14.2) | 0.935 | 1.01 (0.72–1.43) | 79 (12.9) | 83 (13.8) | 0.668 | 0.93 (0.65–1.32) | |
| Allele | |||||||||
| A | 797 (63.1) | 768 (63.5) | 790 (64.4) | 769 (63.8) | |||||
| G | 467 (36.9) | 442 (36.5) | 0.817 | 1.02 (0.87–1.20) | 436 (35.6) | 437 (36.2) | 0.726 | 0.97 (0.82–1.15) | |
*
Adjusted by age and sex status.