Table 5. Haplotype analyses in the two populations.
| Han population | Tibetan population | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene/haplotype | Case (%), n=1264 | Control (%), n=1210 | P | OR (95% CI) | Case (%), n=1226 | Control (%), n=1210 | P | OR (95% CI) |
| TLR2 | ||||||||
| ACCG | 342.1 (27.1) | 302.4 (25.0) | 0.235 | 1.12 (0.93–1.34) | 249.0 (20.3) | 238.1 (19.8) | 0.817 | 1.02 (0.84–1.25) |
| ACTG | 27.4 (2.2) | 44.7 (3.7) | 0.025 | 0.58 (0.36–0.94) | ||||
| ATTG | 380.3 (30.1) | 321.0 (26.5) | 0.048 | 1.19 (1.00–1.42) | 393.0 (32.1) | 351.9 (29.2) | 0.165 | 1.13 (0.95–1.35) |
| GTTG | 497.7 (39.4) | 527.0 (43.6) | 0.035 | 0.84 (0.72–0.99) | 558.0 (45.5) | 579.1 (48.1) | 0.140 | 0.89 (0.75–1.04) |
| Other* | 14.4 (0.01) | 15.0 (1.2) | 26.0 (2.1) | 34.9 (2.9) | ||||
| TLR4 | ||||||||
| CTGG | 318.4 (25.2) | 320.9 (26.5) | 0.429 | 0.93 (0.78–1.11) | 417.6 (34.1) | 377.9 (31.4) | 0.149 | 1.13 (0.96–1.34) |
| TCCG | 297.9 (23.6) | 304.6 (25.2) | 0.335 | 0.91 (0.76–1.10) | 188.4 (15.4) | 222.9 (18.5) | 0.040 | 0.80 (0.65–0.99) |
| TCGG | 464.5 (36.8) | 424.6 (35.1) | 0.410 | 1.07 (0.91–1.26) | 464.3 (37.9) | 446.8 (37.1) | 0.670 | 1.04 (0.88–1.22) |
| TTGC | 108.3 (8.6) | 93.0 (7.7) | 0.433 | 1.12 (0.84–1.50) | 70.2(5.7) | 85.3 (7.1) | 0.175 | 0.80 (0.58–1.11) |
| TTGG | 54.4 (4.3) | 44.6 (3.7) | 0.441 | 1.17 (0.78–1.76) | 59.6 (4.9) | 47.9 (4.0) | 0.286 | 1.24 (0.84–1.82) |
| Other* | 20.5 (1.6) | 22.3 (1.8) | 25.9 (2.1) | 23.2 (2.0) | ||||
| TOLLIP | ||||||||
| CCG | 463.9 (36.7) | 400.0 (36.4) | 0.879 | 1.01 (0.86–1.19) | 433.5 (35.4) | 4345.0 (36.1) | 0.705 | 0.97 (0.82–1.14) |
| CTA | 402.9 (31.9) | 379.6 (31.4) | 0.803 | 1.02 (0.86–1.21) | 433.8 (35.4) | 392.1 (32.6) | 0.137 | 1.14 (0.96–1.35) |
| TTA | 384.1 (30.4) | 376.4 (31.1) | 0.682 | 0.97 (0.81–1.15) | 343.2 (28.0) | 362.9 (30.1) | 0.250 | 0.90 (0.76–1.08) |
| Other* | 13.1 (1.0) | 14.1 (1.2) | 15.6 (1.2) | 14.1 (1.2) | ||||
*
Those with lowest frequency threshold (LFT) < 0.03 were pooled in this part.