Table 1.
Angiotensin (Ang)-(1-7) and body composition in aged mice.
| Parameter, Unit | Young Saline | Young Ang-(1-7) | Aged Saline | Aged Ang-(1-7) | P Age | P Drug | P Int |
|---|---|---|---|---|---|---|---|
| n | 10 | 10 | 8 | 10 | |||
| Body composition | |||||||
| Body mass, g | 30.0 ± 0.8 | 30.9 ± 0.6 | 46.1 ± 1.7 *† | 44.4 ± 1.6 *† | 0.001 | 0.740 | 0.302 |
| Adiposity, % | 7.0 ± 0.5 | 7.2 ± 0.7 | 14.6 ± 1.7 *† | 16.7 ± 1.5 *† | 0.001 | 0.328 | 0.451 |
| Lean mass, % | 69.7 ± 0.8 | 69.3 ± 0.9 | 60.7 ± 1.9 *† | 58.2 ± 1.3 *† | 0.001 | 0.251 | 0.403 |
| Fluid mass, % | 6.9 ± 0.1 | 6.7 ± 0.1 | 8.6 ± 0.2 *† | 8.4 ± 0.1 *† | 0.001 | 0.207 | 0.969 |
| Adipose and heart tissue weights | |||||||
| EPF, % | 1.3 ± 0.2 | 1.6 ± 0.3 | 2.8 ± 0.5 | 3.7 ± 0.5 *† | 0.001 | 0.152 | 0.457 |
| SCF, % | 1.0 ± 0.1 | 1.1 ± 0.2 | 2.3 ± 0.5 | 3.2 ± 0.4 *† | 0.001 | 0.178 | 0.278 |
| BAT, % | 0.29 ± 0.05 | 0.29 ± 0.03 | 0.44 ± 0.06 † | 0.45 ± 0.02 *† | 0.001 | 0.809 | 0.877 |
| Heart, % | 0.36 ± 0.06 | 0.44 ± 0.01 | 0.48 ± 0.02 | 0.45 ± 0.03 | 0.038 | 0.362 | 0.085 |
Data are mean ± SEM and were analyzed by two-way ANOVA for main effects of age (PAge) and Ang-(1-7) versus saline treatment (PDrug) as well as their interaction (PInt) in young adult and aged mice. * p < 0.05 versus young saline and † p < 0.05 versus young Ang-(1-7) from post-hoc pairwise comparisons with Tukey correction for multiple comparisons. Body composition measurements and adipose and heart tissue weights are expressed as a percentage of total body mass. EPF, epididymal visceral white adipose tissue; SCF, inguinal subcutaneous white adipose tissue; BAT, interscapular brown adipose tissue.