Table 2.
Subset of dysregulated mitochondrial proteins identified by LFQ proteomics in MUT-KO.
| UniProt Accession | Protein Name | Gene Name | Regulation | Log2 Difference |
|---|---|---|---|---|
| P22033 | Methylmalonyl-CoA mutase, mitochondrial | MUT | DOWN | −8.4 |
| P23434 | Glycine cleavage system H protein, mitochondrial | GCSH | DOWN | −3.8 |
| Q99595 | Mitochondrial import inner membrane translocase subunit Tim17-A | TIMM17A | DOWN | −3.3 |
| Q8N4T8 | Carbonyl reductase family member 4 | CBR4 | DOWN | −3.1 |
| Q9NUQ2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon | AGPAT5 | DOWN | −3.0 |
| Q9Y375 | Complex I intermediate-associated protein 30, mitochondrial | NDUFAF1 | DOWN | −2.7 |
| Q13772 | Nuclear receptor coactivator 4 | NCOA4 | DOWN | −1.1 |
| P02794 | Ferritin heavy chain | FTH1 | DOWN | −0.9 |
| P32119 | Peroxiredoxin-2 | PRDX2 | UP | 0.8 |
| P27105 | Erythrocyte band 7 integral membrane protein | STOM | UP | 0.8 |
| Q13057 | Bifunctional coenzyme A synthase | COASY | UP | 0.9 |
| Q9H2U2 | Inorganic pyrophosphatase 2, mitochondrial | PPA2 | UP | 0.9 |
| Q6YN16 | Hydroxysteroid dehydrogenase-like protein 2 | HSDL2 | UP | 1.0 |
| Q16698 | 2,4-dienoyl-CoA reductase, mitochondrial | DECR1 | UP | 1.0 |
| P35270 | Sepiapterin reductase | SPR | UP | 1.0 |
| P23786 | Carnitine O-palmitoyltransferase 2, mitochondrial | CPT2 | UP | 1.0 |
| Q8WVC6 | Dephospho-CoA kinase domain-containing protein | DCAKD | UP | 1.0 |
| P35914 | Hydroxymethylglutaryl-CoA lyase, mitochondrial | HMGCL | UP | 1.0 |
| P12532 | Creatine kinase U-type, mitochondrial | CKMT1A | UP | 1.1 |
| Q9BRX8 | Redox-regulatory protein FAM213A | FAM213A | UP | 1.2 |
| Q9NP58 | ATP-binding cassette sub-family B member 6, mitochondrial | ABCB6 | UP | 1.4 |
| Q9NRG7 | Epimerase family protein SDR39U1 | SDR39U1 | UP | 1.4 |
| Q9Y2Z9 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial | COQ6 | UP | 1.7 |
| Q14790 | Caspase-8 | CASP8 | UP | 1.8 |
| Q86UT6 | NLR family member X1 | NLRX1 | UP | 2.1 |
| Q9BVL4 | Selenoprotein O | SELO | UP | 2.4 |
| Q6PML9 | Zinc transporter 9 | SLC30A9 | UP | 2.4 |
| O95139 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | NDUFB6 | UP | 2.7 |
| A8MXV4 | Nucleoside diphosphate-linked moiety X motif 19, mitochondrial | NUDT19 | UP | 3.6 |
| Q8IYQ7 | Threonine synthase-like 1 | THNSL1 | UP | 3.7 |
| Q9BSF4 | Uncharacterized protein C19orf52 | C19orf52 | UP | 4.0 |
| Q9P0M9 | 39S ribosomal protein L27, mitochondrial | MRPL27 | UP | 4.5 |
| P00395 | Cytochrome c oxidase subunit 1 | COX1 | UP | 5.7 |