Figure 5.

Activation of a platelet, inside-out and outside-in signalling upon ligation of major platelet membrane receptors. Adapted from [40,76,86,90,98]. Abbreviations: GPCR, G-protein coupled receptor; GPVI, glycoprotein VI; VWF, von Willebrand’s factor; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; SFK, Scr family kinases; Syk, spleen tyrosine kinase; PLC, phospholipase C; LAT, linker for activation of T-cells; DAG, diacylglycerol; IP3, inositol triphosphate; PKC, protein kinase C; Ca²⁺, calcium ions; Cal-DAG-GEFI, diacylglycerol regulated guanine nucleotide exchange factor I; GDP, guanine diphosphate; GTP; guanine triphosphate; RASA3, Ras GTPase-activating protein 3; RIAM, Rap1-GTP interacting adapter molecule; MAPK, mitogen-activated protein kinase; TXA2, thromboxane A2; GAP, GTPase activating protein; PI3K, phosphatidylinositide 3-kinase. This image was made using BioRender (https://biorender.com/).