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Mechanism of radiation-induced abscopal effect. Radiation damages tumor cells leading to generation of tumor antigens and neoantigens. Antigen presenting cells (APCs) can pick up these antigens, travel to draining lymph nodes, and present antigens and prime the naïve CD8+ T cells. The primed and activated T cells circulate to both the primary irradiated tumor and non-irradiated metastatic tumor sites and attack these tumors; hence generating the abscopal effect.
