Figure 1.

Gene expression analysis of tumor cells in orthotopic and metastatic sites of the orthotopic small cell lung cancer metastasis model. (A) Cells from the orthotopic and metastatic sites of the orthotopic metastasis model developed using DMS273 cells were subjected to DNA microarray analysis. (B) Schematic representation of the isolation of tumor cells from orthotopic and metastatic sites in the mice. (C) A clustering analysis of the 43 differentially expressed genes (p < 0.01, fold change > 4) between the orthotopic and metastatic tumors.