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. 2020 Jul 17;21(14):5042. doi: 10.3390/ijms21145042

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Simplified model for the role of TGase 2 in HIF-1α activation. HIF-1α and p53 both require interaction with the transcriptional co-activator p300 for stable transcriptional activity. Interference of each protein with the transcriptional activity of the other is related to the availability of p300 [18,19]. TGase 2-mediated p53 depletion induces angiogenesis by promoting the HIF-1α–p300 interaction in RCC. The TGase 2 inhibition-mediated increase in apoptosis was attributed to increased p53–p300 binding.