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. 2020 Jul 12;21(14):4923. doi: 10.3390/ijms21144923

Figure 1.

Figure 1

Schematic drawing of miR-29a, acetyl histones, and methyl histone regulation of osteoblast function and bone integrity. miR-29a targets HDAC4, increasing H3K9ac binding promoters for miR-29a and Dkk-1. H3K9ac interacts with BRD4 to affect Foxp1 transcription. miR-29a targets PCAF, decreasing H3K27ac enrichment in CXCL12 promoter (a). miR-29a interacts with UTX and EZH2, regulating H3K27me3 binding promoters for Wnt and SOST to modulate osteogenic differentiation. UTX modifies methylation of Runx2, osterix, and FNDC5 promoters to regulate osteogenic differentiation capacity (b).