4-HNE |
4-hydroxy-noenal |
AA |
Arachidonic acid |
ACC |
Acetyl-CoA carboxylase |
ACSL4 |
Acyl-CoA synthetase long-chain family member 4 |
ALD |
Acute liver disease |
ALOXs |
Arachidonate lipoxygenases |
AREs |
Antioxidant response elements |
ATG5-7 |
Aumiddlehagy protein 5 and 7 |
bZIP |
Basic leucine zipper |
CBS |
Cystathionine β-synthase |
CDKN1A/p21 |
Cyclin-dependent kinase inhibitor 1A |
CISD1 |
CDGSH iron sulfur domain 1 |
CLD |
Chronic liver disease |
CoQ10 |
Coenzyme Q10 |
CRC |
Colorectal cancer |
DAMPs |
Damage-associated molecular patterns |
DCYTB |
Duodenal cytochrome B reductase |
DFO |
Deferoxamine |
DILI |
Drug-induced liver injury |
DMT1 |
Divalent metal transporter 1 |
DPP4 |
Dipeptidyl-peptidase 4 |
ER |
Endoplasmic reticulum |
Fe2+
|
Ferrous iron |
Fe3+
|
Ferric iron |
FECH |
Ferrochelatase |
Fer-1 |
Ferrostatin-1 |
FPN |
Ferroportin |
FSP1 |
Ferroptosis suppressor protein 1 |
FTH1 |
Ferritin heavy chain |
FTL |
Ferritin light chain |
GGT |
γ-Glutamyl transpeptidase |
GLC |
γ-Glu-Cys-ligase |
GPX4 |
Glutathione peroxidase 4 |
GSR |
Glutathione reductase |
GSH |
Glutathione |
GSS |
Glutathione synthetase |
HATs |
Heterodimeric amino acid transporters |
HCC |
Hepatocellular carcinoma |
HCP-1 |
Heme carrier protein-1 |
HO-1 |
Heme oxygenase-1 |
HSC |
Hemamiddleoietic Stem Cell |
HSPs |
Heat shock proteins |
HSPB1 |
Heat shock factor-binding protein 1 |
IREB2 |
Iron-responsive element-binding protein 2 |
IRI |
Ischemia–reperfusion injury |
Keap1 |
Kelch-like ECH-associated protein 1 |
LC3-I/II |
Microtubule-associated protein light chain 3 |
LIP |
Labile iron pool |
Lip-1 |
Liproxstatin-1 |
LPCAT3 |
Lysophosphatidylcholine acyltransferase 3 |
MAPKs |
Mitogen-activated protein kinases |
MDA |
Malondialdehyde |
MRP/ABCC |
Multidrug resistance-associated proteins |
MT-1G |
Metallothionein-1G |
NAFLD |
Non-alcoholic liver disease |
NAPQI |
N-acetyl-p-benzoquinone imine |
NASH |
Non-alcoholic steatohepatitis |
NCOA4 |
Nuclear receptor coactivator 4 |
Nrf2 |
Nuclear factor erythroid 2-related factor |
OMM |
Outer mitochondrial membrane |
OXPHOS |
Oxidative phosphorylation |
PARP1 |
Poly [ADP-ribose] polymerase 1 |
PC |
Phosphatidylcholine |
PE |
Phosphatidylethanolamine |
PEPT1-2 |
Proton-coupled oligopeptide transporter family members 1 and 2 |
PKC |
Protein kinase C |
PS |
Phosphatidylserine |
PUFAs |
Polyunsaturated fatty chains |
Rb |
Retinoblastoma |
RCD |
Regulated cell death |
ROS |
Reactive oxygen species |
RPTECs |
Renal proximal tubular epithelial cells |
RSL3/5 |
Ras-selective lethal small molecule 3/5 |
RTA |
Radical-trapping antioxidant |
SAS |
Sulfasalazine |
SAT1 |
Spermidine/spermine N1-acetyltransferase 1 |
SOD3 |
Superoxide dismutase 3 |
STEAP3 |
Six-transmembrane epithelial antigen of prostate 3 |
Tf |
Transferrin |
TGFβ |
Transforming growth factor beta |
TRF1 |
Transferrin receptor protein 1 |
TXN |
Thioredoxin |
TXNRD1 |
Thioredoxin reductase 1 |
VDACs |
Voltage-dependent anion channels |