Table 2.

Ferroptosis inducers (adapted from [25]).

Class	Class Characteristics	Impact on Ferroptosis	Compound Examples	Suitable for In Vivo Use
Class 1	Inhibition of system Xc−	Prevention of cystine import, GSH depletion, loss of GPX4 activity	Erastin, sulfasalazine, sorafenib	Sorafenib, sulfasalazine
Class 2	Direct inhibition of GPX4	Covalent interaction with GPX4 and inhibition of the enzyme	RSL3, RSL5	No
Class 3	Depletion of GPX4 protein and CoQ10	Depletion of GPX4 and CoQ10	FIN56	Unknown
Class 4	Induction of lipid peroxidation	Oxidation of iron drives lipid peroxidation and indirect inactivation of GPX4	FINO2	Unknown