Figure 1.

Pathogenic germline variants reported in the established, and potentially clinically actionable, PrCa predisposing genes recommended for genetic testing for PrCa [30,53,55,58,82,87,88,89,90,96,115,116,117,118,119,120] (Table S1). Missense variants classified as “pathogenic/likely pathogenic” by ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/, accessed in 20 May 2020) are also represented on each gene. The location of the variants is shown by lollipop structures. The x-axis represents the number of amino acid residues and displays the protein domains encoded by each gene.