Table 1.
Drug Class | Lysosomotropic Drug | |
---|---|---|
Antidepressants (tricyclic) | Amitriptyline (++) Imipramine (++) Trimipramine (++) Maprotiline (++) Clomipramine # x/*** |
Nortriptyline (++) Desipramine (++) Doxepine (++) Protriptyline (+) |
Antidepressants (SSRI) | Fluoxetine (+) Setraline (++) |
Norfluoxetine (+) Paroxetine (+) |
Antimycotics | Terbinafine # (++) | |
Antipsychotics |
Chlorpromazinex/xx (++) Promazine (++) |
Levomepromazine (++) Promethazinex (+) |
Neuroleptics | Chlorprothixene (++) Thioridazine (++) Thiothixene x/*** |
Perazine (++) Triflupromazine x/** Fluspirilene x/## |
Tyrosine kinase inhibitors | Imatinib #x/*** | Dasatinib #x/*** |
Calcium channel blockers | Amlodipine (-) | |
Antirheumatics (antiprotozoals) |
Chloroquinex/xx (++) Mefloquine #ox/*** |
Hydroxychloroquinex/xx (++) |
Ovulation inducers | Clomiphene (++) | |
Estrogen Receptor Antagonist | Toremifene #x/*** | |
H1-antihistaminics | Astemizolex * | Terfenadine (++) |
Anticholinergics (H1-antihistaminics) | Benzatropinex (-), | |
Antibiotics (glycopeptides) |
Teicoplaninx/*** Oritavancinx/*** |
Dalbavancinx/*** Telavancinx/*** |
Achievement of the desired lysosomotropic effect depends on the active compound, the dosage, and accumulation in lysosomes. Unless indicated, maximum daily doses are split into three applications. Lysosomal drug concentration (effect) within the therapeutic margin in vivo (expected): (++) occurs at maximum daily dosage and is very likely in low or initial dosage, (+) very likely at maximum daily dosage and is possible in low or initial dosage, (o) possible at maximum daily dosage and unlikely in low or initial dosage, and (-) unlikely even at maximum daily dosage; * withdrawn from the market (in most countries); ** veterinary use only; dosage: # single dose per day, #o dosage depending on treatment or prophylaxis (of malaria); xin vitro anti SARS-CoV tested, xxin vitro anti SARS-CoV-2 tested [28,29,36,41,42,45,131,132]; *** lysosomotropism very likely, but not yet confirmed, lysosomal drug concentration (effect) within the therapeutic margin expected; ## lysosomotropism very likely, but not yet confirmed, no lysosomal drug concentration (effect) within the therapeutic margin expected.