. 2020 Jul 13;21(14):4953. doi: 10.3390/ijms21144953

Table 1.

Variety of approved lysosomotropic compounds for various indications [36,41,42].

Drug Class	Lysosomotropic Drug
Antidepressants (tricyclic)	Amitriptyline (++) Imipramine (++) Trimipramine (++) Maprotiline (++) Clomipramine ^{# x}/***	Nortriptyline (++) Desipramine (++) Doxepine (++) Protriptyline (+)
Antidepressants (SSRI)	Fluoxetine (+) Setraline (++)	Norfluoxetine (+) Paroxetine (+)
Antimycotics	Terbinafine ^# (++)
Antipsychotics	Chlorpromazine^x/xx (++) Promazine (++)	Levomepromazine (++) Promethazine^x (+)
Neuroleptics	Chlorprothixene (++) Thioridazine (++) Thiothixene ^x/***	Perazine (++) Triflupromazine ^x/ Fluspirilene ^x**/^##
Tyrosine kinase inhibitors	Imatinib ^#^x/***	Dasatinib ^#^x/***
Calcium channel blockers	Amlodipine (-)
Antirheumatics (antiprotozoals)	Chloroquine^x/^xx (++) Mefloquine ^#o^x/***	Hydroxychloroquine^x/^xx (++)
Ovulation inducers	Clomiphene (++)
Estrogen Receptor Antagonist	Toremifene ^#^x/***
H₁-antihistaminics	Astemizole^x *	Terfenadine (++)
Anticholinergics (H₁-antihistaminics)	Benzatropine^x (-),
Antibiotics (glycopeptides)	Teicoplanin^x/* Oritavancin^x/*	Dalbavancin^x/* Telavancin^x/*

Achievement of the desired lysosomotropic effect depends on the active compound, the dosage, and accumulation in lysosomes. Unless indicated, maximum daily doses are split into three applications. Lysosomal drug concentration (effect) within the therapeutic margin in vivo (expected): (++) occurs at maximum daily dosage and is very likely in low or initial dosage, (+) very likely at maximum daily dosage and is possible in low or initial dosage, (o) possible at maximum daily dosage and unlikely in low or initial dosage, and (-) unlikely even at maximum daily dosage; * withdrawn from the market (in most countries); ** veterinary use only; dosage: ^# single dose per day, ^#o dosage depending on treatment or prophylaxis (of malaria); ^xin vitro anti SARS-CoV tested, ^xxin vitro anti SARS-CoV-2 tested [28,29,36,41,42,45,131,132]; *** lysosomotropism very likely, but not yet confirmed, lysosomal drug concentration (effect) within the therapeutic margin expected; ^## lysosomotropism very likely, but not yet confirmed, no lysosomal drug concentration (effect) within the therapeutic margin expected.