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Scheme of the configuration of the dual-channel PIE-FLIM to simultaneously obtain Granada Green-2,4-dinitrophenylsulfonyl (GG-DNBS) biothiol probe and Aβ-647 aggregates images. For determining the rate of the fluorogenic biothiol reaction, the average pixel intensity in the regions of interest (black points) were fitted to a sigmoidal function (line red) and the slope at the inflection point (line green) was calculated.
