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. 2020 Jul 20;21(14):5137. doi: 10.3390/ijms21145137

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effects of ruxolitinib treatment on molecules related to the Wnt/β-catenin signaling pathway. The mRNA expression of (A) Wnt7, (B) Lef1, (C) β-catenin, (D) DKK1, and (E) TGF-β in hDPCs. Ruxolitinib activated the mRNA expression of molecules related to the Wnt/β-catenin signaling pathway compared to the control and reverted the effect of IFN-γ in hDPCs. The data represent the means ± SEM, n = 3, statistically significant at * p < 0.05, ** p < 0.01 compared to the control and # p < 0.05, ## p < 0.01 compared to the IFN-γ-treated group.