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. 2020 Jul 20;21(14):5137. doi: 10.3390/ijms21145137

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of ruxolitinib treatment on hair-follicle organ culture. (A) Ruxolitinib pretreatment significantly prevented the induction of MHC class II molecule by IFN-γ in and around the hair follicles in the protection assay; (B) The expression of MHC class II molecule in the hair follicles ruxolitinib administered after treatment with IFN-γ was not effectively suppressed in the restoration assay; (C) Relative number of immune-positive cells of MHC class II molecule in the protection and restoration assay. White arrowheads indicate outline of hair follicles. The data represent the means ± SEM, n = 3, statistically significant at * p < 0.05, and ** p < 0.01 compared to the control and # p < 0.05 compared to the IFN-γ-treated group.

Effects of ruxolitinib treatment on hair-follicle organ culture. (A) Ruxolitinib pretreatment significantly prevented the induction of MHC class II molecule by IFN-γ in and around the hair follicles in the protection assay; (B) The expression of MHC class II molecule in the hair follicles ruxolitinib administered after treatment with IFN-γ was not effectively suppressed in the restoration assay; (C) Relative number of immune-positive cells of MHC class II molecule in the protection and restoration assay. White arrowheads indicate outline of hair follicles. The data represent the means ± SEM, n = 3, statistically significant at * p < 0.05, and ** p < 0.01 compared to the control and # p < 0.05 compared to the IFN-γ-treated group.